Quaternary Associations of Acetylcholinesterase

The Interaction of Quaternary Reversible Acetylcholinesterase Inhibitors with the Nicotinic Receptors

The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor.

Acetylcholinesterase inhibitors (AChEIs) are used in the treatment of myasthenia gravis (MG). We investigated the effects of AChEIs on peripheral nicotinic receptors (nAChR), which play a crucial role in the treatment of MG symptoms. The positive modulation of those receptors by AChE inhibitors could have an added value to the anti-AChE activity and might be useful in the therapy of MG. Further...

Molecular dynamics of acetylcholinesterase.

Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site. The most recent work points to the complex and spatially extensive nature of such motions and suggests possible modes ...

Inhibitors of Acetylcholinesterase

Turnover time of acetylcholinesterase.

The turnover time of the enzyme, acetylcholinesterase, is of biological interest because of the role proposed for its substrate in nerve conduction. According to the theory of Nachmansohn, the action of acetylcholine on a receptor protein is responsible for the generation of bioelectric potentials by increasing sodium conductance. Acetylcholinesterase, which inactivates acetylcholine by hydroly...